You can autolevel connected to the truck. I have a 3950 and do it every day while traveling. The only time I disconnect is if the spot is not big enough for the whole rig or I need to go somewhere after I am parked.
There is a learning curve with the system and you will learn with each setup. On occasion I have had to use manual mode, but I have not figured out how to get the center jacks down in this mode.
My last trip was three weeks long and I moved every day except 2 and those 2 stops are the only time I disconnected from the truck.