When we took vacations during the winter and came to Florida I would drive 22 hours (all night) without a break. Didn't want to waste limited time off.
Being retired and full time in the RV is TOTALLY different for us. We average a maximum of 300 to 325 miles a day, don't really like breaking camp until after 9am, and prefer to be set up in the next CG by 3:30pm.
I would rather have full hook-ups each night to take advantage of all the comfort and systems my RV is equipped with, and I paid for. In addition to our slower pace across the country, we generally like to find an interesting location to spend 3 or 4 days at if we have traveled several days in a row.
If an emergency would come up I guess we would spend the night at a rest area or truck stop, but have avoided it so far.