2000 class C E350 V10 Ford

As midnightesadie stated, check your fuel pump. After going through all of the above on ours, we determined the pump had failed. This, unfortunately, is a very common issue on this era of Fords.

Failure & replacement of fuel pump on E-350

My E350 fuel filter is located on driver side frame. As I recall you need an inexpensive special tool to remove the filter.

Common problem is the solenoid.
And no it won't click when you try to start it. It just won't start. Been there done that.

There are 4 or 5 solenoids on it. Hope its not the one on the starter unlike in the old days because now it is an assembly and you have to buy a whole new starter.

The one that seems to be the one to go out is located on the inside right front fender. RV mobile repair guys know right where to look ir's such a common problem. Easy fix, cheap part.

All you have to do is have someone check each solenoid while you sit inside turning the key. That will tell you which one is not working.

Try this: on many vehicles there is a switch that turns off the fuel pump in case of an accident and it's located in the footwell-dash area on the passenger side of a Ford vehicle. Your owners manual should show you where it is. Check it and maybe a reset is all you need.

just a guess but I don,t think its your filter, some of the rv,s never get there filter changed in the life of the rv. try this takes to people ,open the fuel door take off the cap and put your ear down there ,have some one turn the key to start but not crank, you should be able to here the fuel pump pumping,, if not you most likely have a fuel delivery problem.

Look on the inside of the left frame rail a little behind the transmission