If your 460-powered Class C was 1980's then it had the three-speed automatic transmission called C6 which had no overdrive. The "last" of the 460's was the 1996 model year and by then they had the E4OD, OD meaning Overdrive. The early E4OD had some problems but they were worked out toward the end of the 460's run. When the V10 came out in 1997 (Chassis Year!) Ford applied electronic control to the E4OD and it became known as 4R100, again an overdrive transmission. The 1997-99 V10 had 275HP and a number of them had problems with sparkplugs blowing out since they had only a few threads. Ford addressed this with PI (performance improved) heads and 305HP. Unfortunately some of those heads still spit the plugs out because the holes (with a proper number of threads) weren't properly machined into line with the plugs' seating surfaces. This affected only some of the heads, according to the plant that supplied them. The machinery does all plug holes at once, the same error would apply to all as to one hole. All three on a V6 head, all four on a V8, five on a V10.
I tried to research if our 2002 V10 was OK and a professional checked with a rebuilder. Came back saying OK. In 40,000 miles we have not had an issue. Not with engine, transmission, really ANY Ford-provided part of the coach.
Like you, we had a 1980's 460 in a Class C. I liked its brute off-the-line torque. The V10 has to wind up a little, but the power is there, and probably more. I'm a fan of V8's. Would like to see what a 460, tricked out like V10 is, would do in our 31-ft Class C. I have to remember it weighs easily a ton more then the old one did.
I'd rather have a 1994-96 460 than a 1997-99 V10. But we really don't get a choice. The Year is going to determine the Engine.