For what it's worth - our 2005 V10 Class C motorhome (2005 E450 chassis under a 2005 Winnebago-Itasca coach) came from Ford with a computer controlled TorqShift 5R110 5-speed (6 speeds internally) transmission in it. Our Class C has a little over 51K miles on it.
Last Thursday the 5R110 transmission experienced serious failure leaving our driveway and we barely made it into town with it. By Friday afternoon, a factory rebuilt transmission was installed in it so that we could begin an RV trip across the country. I hope the factory rebuild holds up.