HI Ol 'yeller,
All that holds the slide in is either the gear, or hydraulic strut (depending on which type you have). We saw the results where the driver swerved to avoid a deer, which caused his travel trailer to whip in a high speed s curving motion. The lateral g forces overloaded the slide mechanism, and it came out. This caused the trailer to flip, and dragged the truck over on it's side. The dealer told us to always use the lock when we got our trailer in 2005, and we always did.
We hung an orange ribbon off of the slide lock to make sure that we didn't forget it.
Having said that, I don't know if a Class C would ever experience that kind of lateral load on the slide. But what the heck, it couldn't hurt.
In a travel trailer, I would say to always use it. In a class C, I really don't know. But, since it came with one, go ahead and take the 30 seconds to use it. There is probably a good reason why the manufacturer included it.