Get them balanced.
When I bought my current coach (42' with tag, weighs nearly 40,000 pounds), the dealer put new tires on. He said he put balancing powder in all the wheels.
On our first long trip with the coach we had an annoying vibration. So, I had a tire shop removed the powder from the steer tires, spin balance and I also put Centramatics on the steer axle. It was much better but we could still feel some vibration/tire hop from somewhere.
We visited Les Schwab in Junction City, OR and had them remove one of the rear tires to see if there was powder in them. There was not so I had them spin balance all the drive axle and tag axle tires. The vibration went away after that. These were Michelin XZA2 Energy tires so not cheap.
I am a believer in balancing all the tires.