I like to disconnect the batteries, both house and chassis, charge them slowly until full, then leave alone until spring time. Recharge in spring, hook up, and all is well. But this is done in a heated garage. If I kept the rig outside in winter, I would bring in the batteries.
I don't run the engine or generator every-other week like other people recommend. I think it can do more harm than good. But again, our rig is in heated storage which may make all the difference. I practice this on all my winter-stored vehicles including collector cars. Been doing so for 25 years.