My MIL lived in La Jolla, so we made many trips from Durango to San Diego with our motorhome. We have stayed in three places of which I would only enthusiastically recommend one. The Chula Vista Marina and RV Resort, which is a bit south of town on I-5, but easy to get in and out of from the interstate. We also stayed many times at Campland on the Bay (Mission Bay) in Pacific Beach. It was very handy for our needs and comfort, but we did not love the place. Lots of little ants, among other things. We stayed in the Mission Bay RV Resort once, but it was not a friendly place and had few amenities. (Drove over their speed bump at about 1 MPH and a cupboard spewed a lot of, it turns out, highly breakable Melamine onto the floor!) If you don't need the proximity to SD, then look at the places in Oceanside, which would be more fun.