Can a portable generator be hooked up as a permanent one?

On our first Class C we mounted a generator on hitch carrier. Secured it for transport with cargo straps and for theft we used a high quality cable bike lock. Reran the power cord to come out the floor and back to the generator allowing us to be plugged into generator while driving and that allowed us to run the roof air while driving. No problems with exhaust.
If you are going to run a generator anywhere near a RV you should have a CO detector in your RV. .