Most large cities have limited RV overnight facilities and do not allow parking of RV's in the street. Indoor parking facilities have low ceilings, RV's cannot park. Definitely have a GPS to find your way through and preferably around big cities. Beware of your RV side mirrors tangling with adjacent truck mirrors. Don't make the common mistakes of leaving the TV antenna cranked up and and/or trying drive through a fast food place with low clearance.
General advice, don't try to find an RV park after dark unless you have called ahead and reserved a spot. Some Walmarts and truck stops welcome RV'ers that merely want to park and sleep. Overnight RV parking at some Walmarts is prohibited by law in some localities. Use judgment about safely parking overnight where you won't be bothered.