There was an article in Trailer Life magazine about five months ago on cold weather RVing. I think that a fifth wheel with the right equipment would work. Now that said, you will need one built from the ground up for cold weather. A lot of the trailers use the furnance to heat the holding and fresh water tanks. This is a consideration due to the use of propane to heat. If you have an electrical supply, you can use electrical heaters to heat the trailer and only use the fan on the furnanace to circulate the warm air.
As was said above, you will need a heated water hose to bring water to the trailer. Again, dumping the waste tanks can be a PIA in cold weather. Depending on how cold it is and the site you have (sewer provided I would hope) you can leave the sewer hose connected. You can run the grey water through it all of the time but would need to allow the black tank to fill up then dump or you run into problems.
Some RV's (Fifth and MH) have good insulation and some don't. Arctic Fox is made for cold climate use. There are a lot of others but that is the only one that I know of designed with cold weather in mind.
Check out everything before you make a decision.