I've owned two Ford V10s - First, in the Ford Excursion we had for many years that we towed a 34' TT with, and now in our 36' MH. Both were (and are) great.
In both cases, I've never used the cruise control ever, when towing a heavy load (which is all the time with a MH). IMO it (cruise control) just wasn't designed to handle heavy towing very well, for the reasons alluded to here.
Was the same case, really, for previous tow vehicles I owned prior to that as well. I never use cruise control when towing heavy, ever. I've not seen a cruise control system yet, that handles such very well.
That said, I do really like the Ford V10 and torqueshift transmission drivetrain they put in the F53 chassis. It works great, and is pretty much bulletproof, it will not let you over-rev and damage the engine (unless you work really hard at it, haha). Huge improvement over what was available just a few years ago.