I have a 2011 chassis E-350 with the V-10 and have encountered none of the"issues" you described. I can assure you Ford did not program the their computer to skip 4th gear. I think you may have been able to achieve the exact same results by simply having the local Ford dealer reflash your computer. Sometimes they get out of wack and a reflash can work wonders.
The early versions of the V-10 have a reputation for premature shifting and 5 Star tuning makes a good business correcting that but the later models, 2009-2014 are not known to have that issue. Perhaps there is a big difference between your 2010 and my 2011 V-10 but it seems unlikely. You don't mention mileage and I'd be curious to hear what it was before and after.
:h