^^^ I can answer that - it's a big difference. Until a few weeks ago we owned both a MH and a TT.
I have done the western trip with both; hands down without question the MH is more convenient, and comfortable, and easier to drive, and, and, and...
I honestly cannot think of one thing the TT did better or made the trip more enjoyable than the MH. And for the record, we were pulling the TT with an F250 Crew Cab diesel Lariet with the Ultimate package, so we weren't slumming it with the tow truck either.
The TT is now gone.