I need to fill at least one of my two (forward mounted) fresh water tanks to keep enough weight on the front axle for decent handling. Adding an extra 200-300 pounds of water to a 12,000 pound motorhome doesn't make that much difference in miles per gallon, even climbing mountain grades. It makes a lot of difference in the camping experience when I have to overnight where there are no fresh water hookups.
I know, camp with, people who have never filled their fresh water tanks. They will not go anywhere that does not have a water hookup. Some of them don't use their toilets or showers either.