We are currently looking for a Class A and have never driven any type of motorhome (I've driven large box trucks but thats about it). Well we were both pretty nervous but once you find a good salesman and build a rapport, you can pretty much take out anything your heart desires. We have been looking at the Winny Grand Tour 42' and took one of those out on the roads. It definitely did not feel as big as it looked and was SOOOO much easier to drive than I had imagined. if its your first time, just ask the salesman for some tips (like taking the turns wider, preparing for stops, etc) and you'll be fine. I assume you already know most, if not all of this from your experience with the 5th Wheel.