Hypothetical Question about a Chassis

E450 axle is around 4.56 and E350 around 4.10. Some times the tire sizes are different in a bigger truck, but E-Series is the same, so you'll actually get that 10% difference. The 450 also has more steel in the frame, and of course more rear axle capacity. When we went to move up in the Class C world, I specifically wanted the 450. Turned out that in the size we went for it's about mandatory. I'd still do 450 in a smaller coach, the mid-20's sizes.
But gotta say, Bruce's idea of a Chevy 4500 sounds like a good one.

I'd find something I like on the Chevy chassis!

If you were going to be doing a lot of driving you might want to look at the specs on both before deciding.

I think you'll find the F-450 chassis has a lower gear ratio in the rear end.

I have a relatively light and low profile 24' on E450. I can not think of anything which indicates "too much chassis." I almost immediately installed heavier sway bars front and rear-obviously to control what I considered excessive body roll. I also feel the shock absorber control is on the inadequate side, although I haven't replaced them yet. Shocks I think are common part w/ E350. I understand rear gearing is a little shorter with the E450 and in my case seems perfectly appropriate. Maybe on a narrower and even lower profile C the E350 taller gearing would be more appropriate.

So I guess to sum up, I'd consider the E350 only on something smaller, lighter and less top heavy than my 24 Lazy Daze.