Is there a preferred oil for the Ford V10 E-450?

Get a quality filter that doesn’t say Fram on the side of it and any 5W - something is fine.
I generally stick with the lighter weight 5-20 or 5-30 in Triton motors like yours due to the fact that they have smallish oil galleys.
Maybe Frams are better now. Idk and I don’t care. They used to be junk and there are so many other options it’s not worth trying to figure out.
Literally every other 4 stroke engine from lawn mowers to 500hp Hemis and diesels as well get 5-40 or 15-40 diesel oil in my fleet.
I’m sure the Triton would run on 0-40 or 5-40 as well but no need and I only have one of those engines and it doesn’t get a lot of miles and 5-20 5-30 syn can be found for the same price.
Oil brands and weight specificity is largely marketing in most cases (or that extra smidge to bump CAFE numbers).
There’s nothing to pine over here. Proper oil and filter changes are 90% of the equation and specific weights and filters are the other 10%. Just get off the internet and go change the oil and all will be good.

He!!, just ran gallons of 20-50 through a 5.3 LS. No problem but I wouldn’t do it in cold weather. It had a significant leak and the kid drove it about 15k miles daily last year, engine ran fine. (That heavy oil did reduce the cold start piston slap though! Lol) why? If it was coming out the bottom at a quart every 500 miles, I found it for like $12 a gallon.