I have my jacks down when I'm parked at home because I like to put the slide out on occasion. On another note, will it harm the tires if they have weight on them in storage? Do you jack up a vehicle of any kind if it's not going to be used for a period of time? I have a 16 ft trailer that's parked most of the time and never take the weight off the tires or suspension and have not had any issues. A pickup that is a garage queen for months sometimes, no problems.
Do what's comfortable for you.