I was on my last 300 mile leg coming home from a trip in my 'C'. I check the cold tire pressures each morning before pulling out. Everything was fine. When I got home, I pulled it into my building, hopped into my daily driver and went home. The next day, I checked the cold tire pressures. One of the inside duals registered '0' pressure. I drove it carefully to the truck tire shop about two blocks away. They found a large spike still in the tire. So not a blowout, but a slow leak some time on that last leg. I replaced both the inside and outside tires on that side. Then I had a TPMS system installed. Best money I every spent on the RV.
Without tires, you're a park model. :(