Everyone's experience will differ. I enjoy long drives in the car or the motorhome. On several occasions, with the motorhome, I've driven from Southeast GA to Southwest NJ, a 780 mile drive in one day. It's about a 12-14 hour drive depending on traffic. My biggest haul is from Southeast GA to the east/central PA area, around Lebanon, PA. That was a 900 mile trip that was a 15 hour trip.
I don't think driving a motorhome is much more taxing than driving a car, at least not our motorhome. It's a 32' Jayco Class C and drives about the same as my wife's Astro Minivan did with worn pitman arms.
I drive the speed limit as long as the flow of traffic allows it. About 1/2 the drive from North to South is at 70 mph, most of that with Cruise Control on. I stop 3 times for gas and try to avoid eating away from the MH.
I'm 39 now; I'm guessing when I am older I will not be able to drive the same amount, but hopefully by then we'll be full timing it and won't have to drive that much.
I think Chuck summed it up nicely:
cjoseph wrote:
Some people can drive long hours, some can't. Know you limitations and stay safe.
-Michael