Take it to a carb specialist. I had my E350 done years ago and lost almost everything over 50mph. Turns out the spec book was for a 650cfm when it really needed a 750cfm. When properly installed and jetted, it improved my mileage 3mpg and ran great at 65-70 mph. On my 302 Ford van I looked for someone to work on the carb/fuel to pass emissions. Found the right guy at the shop next door, who spoke no English, but was a master with the carb. Result, tested out better than a new carb standard, and had to be run by two different testers before the DMV would accept the results.