Also, just as side-comments:
1) The Ford E450 chassis comes (or at least used to come) with a larger diameter driveshaft than the E350 driveshaft, for less vibration in any length motorhome.
2) One can easily improve upon any negatives of the E450's higher rear differential ratio by using larger diameter tires on the RV. For instance, most E350/E450 based Class C motorhomes come stock with 225/75R 16 size tires. By changing to 215/85R 16 size tires (which are larger in diameter) you partially or fully compensate for the E450's higher rear differential ratio ... plus as a bonus - improve upon tread wear and increase the distance between the rear duals for better airflow cooling of the tire sidewalls in hot weather.