It's really going to come down to picking a floorplan that you like.
Go to lots of shows and as many dealers as possible.
Look at, and walk thru a lot of different motorhomes.
Eventually, you or your DW will get a feel for "what she wants"
In our case, it was "no tv on the dash or windshield" and "totally separate room bathroom"
Of the few coaches with that combo, we chose monoco/HR's 40SKQ floorplan, and from there, we searched the country to find our knight. It was easy then, cause we knew exactly what we were shopping for.