We fulltime in a 25' class C without a towed car. We don't keep a lot of stuff out, either scattered around in the RV or outside, so it's easy to pack up and go. We hook up to the electricity but use the water from our tank and only dump when the waste tanks are full so hookup is simple too.
Parking is rarely a problem. Sometimes we have to walk a few blocks but most of the time we fit in parking lots by backing up over the grass or by taking two spaces.
Leveling can be a pain. Once you get it set up though it's just a matter of driving onto the levelers when you return to your site.
The only thing I'd be concerned about is the cargo carrying capacity. Some Sprinter based RVs have hardly any CCC.