Regarding use of the cab A/C system - whether it be a Sprinter, Ford, Chevy based chassis - it's most effective if you don't expect the cab A/C system to keep cooling fresh incoming hot air from the outside.
Set the cab A/C system to it's recirculate mode so that the system is merely adding cooling to already-cooled interior air. Make sure to have all windows and vents closed to maximize this process. Don't worry about feeling weak from the interior oxygen getting low ... when going down the road there's plenty enough leaks even with all windows/vents closed to supply what our lungs require.
We travel this way in hot weather all the time and rarely has our Ford E450's cab A/C system had to be set to it's highest cooling setting or fan speed setting to keep the coach comfortable from the cab on back. The recirculate mode for our E450's cab A/C system is labeled as "Max A/C".
P.S. When traveling this way you also keep the coach interior nearly free of outside airborn dust/dirt, keep the interior air nearly free of other vehicles' exhaust fumes, and keep the interior air nearly free of slaughter yard/etc. smells. ;)