Blue Buffalo. or Taste of Wild? update on Bud
I want to change Buds food and Tractor supply has these and there own high end brand. Which would you go with?
Forum Discussion
rockhillmanor wrote:
IMHO knowing the facts that the ingredient Milbemycin oxim 'causes' seizures in collies I would NOT give him any more of that Sentinel product.
The active ingredient in all heartworm "preventatives" can cause toxicosis in dogs that are "affected" with MDR1-1delta at lower doses than "normal" dogs. When I say all I mean: ivermectin (HeartGard), milbemycin oxime (Interceptor and Sentinel), moxidectin (Proheart), selamectin (Revolution), and doramectin (Decomax). All of these drugs (all are avermectins) have the same mode of action and interact with the P-glycoprotein blood-brain transport mechanism in the same way. That does not leave any heartworm preventative for use if as is implied one of avermectins is triggering seizures in a seizure prone dog at the heartworm preventative dose.
The other problem with this logic is that "milbemycin oxime 'causes' seizures in collies" is not the same thing as triggering seizures in seizure prone dogs; neurotoxicosis is different than general seizures.
