Forum Discussion
rockhillmanor
Oct 22, 2015Explorer II
NO!! I really doubt the dosing of an avermectin at the preventive dose has anything to do with his seizures.
The OP stated they are using Sentinel that is milbemycin Oxime based.
IMHO when there is ongoing research on 'some' collies having a mutation related to the use of milbemycin oxime that can cause seizures. It would seem real prudent to stop using that heart worm med that has it as an ingredient.
Which came first the chicken or the egg? Is he seizure prone or induced by the ingredient known to CAUSE them in collies having the mutation?
Either way if it's a known problem in the breed I owned, I sure would change to a different one to eliminate at least one of the possible causes.
NOT all heart worm meds use all the SAME ingredients or are safe for all dogs. Nor do you know which ones your dog might have a reaction to until he does.
Ivermectin-Based Treatment Options:
Selamectin-Based Treatment Options:
Moxidectin-Based Treatment Options:
Milbemycin Oxime-Based Treatment Options:
Lists of which product uses what
http://www.petcarerx.com/article/heartworm-medication-dog-heartworm-prevention-meds/218
http://www.drsfostersmith.com/pic/article.cfm?articleid=580
I gave Sentinel and had 2 dogs on life support almost lost them both.
I gave HeartGuard Plus to a Great Dane that reduced him to a drooling stupor. All given at the recommended dose. Had to do with the specific 'different' added ingredients.
IMHO like in the case of Sentinel and others where you are also treating for fleas etc. Throwing in all the other preventative ingredients in with the heartwormt treatment just compounds the problems with some dogs.
About Pet Owners
2,082 PostsLatest Activity: Jul 31, 2025