Blue Buffalo. or Taste of Wild? update on Bud
I want to change Buds food and Tractor supply has these and there own high end brand. Which would you go with?
Forum Discussion
This link has the full article. There may be a link between the MDR1 mutation and how effective anti epileptic drugs are at managing the disease. The researchers did not find evidence that the mutated body function that makes these dogs more sensitive to drugs was involved with altering how effective anti epileptic drugs are for these dogs.
Association between ABCB1 (MDR1 mutation) Genotype and Seizure Outcome in Collies with Epilepsy
Abstract
Background
Medically refractory seizures are an important problem in both humans and dogs with epilepsy. Altered expression of ABCB1, the gene encoding for p-glycoprotein (PGP), has been proposed to play a role in drug-resistant epilepsy.
Hypothesis
Heterogeneity of the ABCB1 gene is associated with seizure outcome in dogs with epilepsy.
Animals
Twenty-nine Collies with epilepsy being treated with antiepileptic drugs (AEDs).
Methods
Prospective and retrospective cohort study. Dogs were classified as having a good outcome (?1 seizure/month, no cluster seizures) or a poor outcome (>1 seizure/month, with or without cluster seizures) based on owner-completed questionnaire. Serum AED concentrations were measured, and ABCB1 genotyping was performed on buccal tissue samples. Association analyses were performed for genotype and seizure outcome, number of AEDs administered, serum AED concentrations, and incidence of adverse effects.
Results
Fourteen dogs of 29 (48%) were homozygous for the ABCB1-1? mutation (M/M), 11 dogs (38%) were heterozygous (M/N), and 4 dogs (14%) had the wild-type genotype (N/N). Dogs with the M/M genotype were significantly more likely to have fewer seizures and have less AED-related sedation than M/N or N/N dogs (P = .003 and P = .001, respectively). Serum phenobarbital and bromide concentrations did not differ between groups, but the M/N and N/N groups received a larger number of AEDs than the M/M group (P = .014).
Conclusions and Clinical Importance
ABCB1 genotype is associated with seizure outcome in Collies with epilepsy. This cannot be attributed to differences in PGP function, but might be because of intrinsic variations in seizure severity among phenotypes.
Association between ABCB1 (MDR1 mutation) Genotype and Seizure Outcome in Collies with Epilepsy
Abstract
Background
Medically refractory seizures are an important problem in both humans and dogs with epilepsy. Altered expression of ABCB1, the gene encoding for p-glycoprotein (PGP), has been proposed to play a role in drug-resistant epilepsy.
Hypothesis
Heterogeneity of the ABCB1 gene is associated with seizure outcome in dogs with epilepsy.
Animals
Twenty-nine Collies with epilepsy being treated with antiepileptic drugs (AEDs).
Methods
Prospective and retrospective cohort study. Dogs were classified as having a good outcome (?1 seizure/month, no cluster seizures) or a poor outcome (>1 seizure/month, with or without cluster seizures) based on owner-completed questionnaire. Serum AED concentrations were measured, and ABCB1 genotyping was performed on buccal tissue samples. Association analyses were performed for genotype and seizure outcome, number of AEDs administered, serum AED concentrations, and incidence of adverse effects.
Results
Fourteen dogs of 29 (48%) were homozygous for the ABCB1-1? mutation (M/M), 11 dogs (38%) were heterozygous (M/N), and 4 dogs (14%) had the wild-type genotype (N/N). Dogs with the M/M genotype were significantly more likely to have fewer seizures and have less AED-related sedation than M/N or N/N dogs (P = .003 and P = .001, respectively). Serum phenobarbital and bromide concentrations did not differ between groups, but the M/N and N/N groups received a larger number of AEDs than the M/M group (P = .014).
Conclusions and Clinical Importance
ABCB1 genotype is associated with seizure outcome in Collies with epilepsy. This cannot be attributed to differences in PGP function, but might be because of intrinsic variations in seizure severity among phenotypes.
