Blue Buffalo. or Taste of Wild? update on Bud
I want to change Buds food and Tractor supply has these and there own high end brand. Which would you go with?
Forum Discussion
Treatment of MDR1 Mutant Dogs with Macrocyclic Lactones
Milbemycin oxime
is, apart from other indications, an effective heartworm preventative at a minimum recommended oral dose of 0.5 mg/kg at monthly intervals (Interceptor®, Milbemax®). When doses of 0.5-2.5 mg/kg milbemycin oxime were orally applied to ivermectin-sensitive Collies, no clinical signs of neurotoxicosis were observed. Therefore, this compound can be safely used for heartworm prevention in MDR1(-/-) dogs. At higher concentrations of 5-10 mg/kg, as well as at daily dosing protocols of 0.5-2.8 mg/kg, which are normally well tolerated in dogs, milbemycin oxime provoked neurological toxicity in MDR1 mutant dogs including ataxia, salivation and depression.
Milbemycin oxime
is, apart from other indications, an effective heartworm preventative at a minimum recommended oral dose of 0.5 mg/kg at monthly intervals (Interceptor®, Milbemax®). When doses of 0.5-2.5 mg/kg milbemycin oxime were orally applied to ivermectin-sensitive Collies, no clinical signs of neurotoxicosis were observed. Therefore, this compound can be safely used for heartworm prevention in MDR1(-/-) dogs. At higher concentrations of 5-10 mg/kg, as well as at daily dosing protocols of 0.5-2.8 mg/kg, which are normally well tolerated in dogs, milbemycin oxime provoked neurological toxicity in MDR1 mutant dogs including ataxia, salivation and depression.
