Blue Buffalo. or Taste of Wild? update on Bud
I want to change Buds food and Tractor supply has these and there own high end brand. Which would you go with?
Forum Discussion
rockhillmanor wrote:Based upon the data I've linked, one would need to exceed 5-10 pills of the prescribed Milbemycin oxime in order for a MDR1 affected dog to reach toxic levels. "Build up" will not occur if pills are given monthly; complete elimination (below detection limits) occurs within 1 week after dosing; therefore, multiple pills (5-10) would need to be given within a week in order to reach toxic levels. Neither of these scenarios sound "very easy" to me.
If you would have read my post on dosing procedures it is very easy to be giving more than needed which would increase the buildup more so in any dog prone to problems having a mutation or not.
Most of the toxicosis cases I have read (I've read many) either involved off label use of livestock meds at too high of doses, the dogs consumed the meds on their own either directly (got into the meds) or indirectly (consumed livestock manure after livestock was dewormed), or use of these meds (at higher doses) for treating mange in MDR1 affected dogs. I've also read the pharmacokinetic studies on these drugs to learn the uptake, excretion, and environmental survivability after excretion (UV degradation is fast).
