rockhillmanor wrote:
Safety testing required before products are registered may be inadequate. Specifically, Farwell said the beagle is the standard laboratory animal used for companion-animal safety studies, but that breed is not sensitive to spot-on products. “The beagle is not the appropriate animal,” he said. He did not say what changes, if any, the agency would propose on testing protocol.""
Perhaps because the "senstive" breeds are more inbred/less genetically robust (have genetic mutations), in much the same way Collies are "sensitive" to ivermectin due to the MDR1 genetic mutation.
