What you want are R&D test kennels with every breed of dog for testing all drugs before being approved for sale on the market, breed specific doses and side effects should be determined for every drug, and there should be breed specific dose packages.
Perhaps instead of testing drugs on breeds with varying levels of genetic mutations to assess for "sensitivities" across the various breeds; breeders and breed organizations should be breeding dogs with fewer genetic mutations (more like the less sensitive test beagles).
IMO when drugs are found to be safe with beagles but not other breeds; the problem is not with the drug but with the genetics of the other breeds (excluding the size differences).
