TRIFEXIS DOES NOT HAVE TIC PROTECTION. The frontline plus is not being used by many now because the fleas, and tics are showing a resistance to the ingredient in it that controls them. It has been used by many, for so long that just like the bugs who become resistance to antibiotics, the same is happening with the Frontline Plus. There are newer products out. We use Trifexis for heartworm/parasite and flea protection. If we need something for tics we use a newer product the vet recommended, or the Vectra collar -- this applies to both north and south areas all over the country.