I may have a fix for the Win 10 Anniversary patch blowing up the USB GPS for S&T. Background - am running Win 10 with S&T 2013 and the USB-attached GPS which had come with my older CoPilot software. Prior to the Anniversary patch it worked fine, and now it didn't find the GPS.
It's an issue with the driver. If you go to Control Panel -> Device Manager and see an error with the PL2303 driver (code 10) then this should fix your issue.
Go here... http://wp.brodzinski.net/hardware/fake-pl2303-how-to-install/
and follow the instructions. You will have to download the older driver found in the instructions and install it. Then using Device Manager you roll back the driver to the older version you just installed. Then have S&T rescan for a GPS.
At least in my case it worked... S&T 2013 on Win 10 Anniversary patch now sees my GPS plugged into one of my USB ports and is working fine.
Hope this helps. I have nothing to do with this fix, just found through Google, ran all the various virus scans etc, seems to be ok. Original source of discussion was in the Microsoft community forums, many people report success.
https://answers.microsoft.com/en-us/windows/forum/windows_10-hardware/prolific-usb-to-serial-comm-port-windows-10/0a4f8e48-7135-4434-9d10-349c9ce87fcf?auth=1
