I wind up using virtualization for everything. However, sometimes, one can find a different program to do the same thing. Instead of the Netscape editor, SeaMonkey does the same thing, and works on W10. Eudora was nice, but the closest available is Thunderbird, which works pretty well, especially with extensions.
Virtualization is nice, especially if one has an old accounting package that does what one needs, can't be updated past Windows XP, OS-wise, and buying a new package is way too expensive with little to gain. One can build a VM, disable all network adapters, copy stuff through the virtualization program, and have one's stuff still run fairly securely, even though the OS may be hideously insecure.
Yes, Windows 10 will run VisiCalc... you can turn on Hyper-V, download FreeDOS and a floppy image of it.