If you're talking about a trailer of some sort then yes, we have had drawers open up and things will shift in the fridge. My wife and three granddaughters rode in our toy hauler for about an hour and wife remarked that it seemed the trailer was trying to beat itself to death. It was a stretch of I-10 in AZ, terrible road. Most of it depends on the road plus these things don't have any shock absorbers. I used to keep the tires at 80 on my previous 5th wheel. My current triple axle toy hauler has less weight on each tire so I keep it at 70 but stuff still happens inside.
