Do they save fuel? SURE!
At what expense? They are a PITA to deal with. Things break or fall off or rub or, or, or, or. Even my awning was ripped from my trailer while driving down the road. I really don't want to deal with this stuff while on vacation.
I race cars and aero is very important for us. BUT the lower we get the car the more problems we have to deal with.
Not only this but they just plain look goofy. Do you really wanted an aero package on the back of your trailer to save .001 MPG?
You can save a lot more just by slowing down just 2 miles / hour.