RV delivery drivers drive all year long. RVs are winterized for the trip, and winter roads are now quickly cleared.
The key is waiting for roads to be cleared. You don't drive when the roads are too slick. You make such slow progress that it is not worth the trouble to drive through conditions where you at best creep along. Sometime you have no choice. Across the Great Plains and to some extent in the Midwest, when driving conditions get to bad the roads are closed. Sometimes for a few hours, sometimes for days.
Mountain roads may be more of an issue. There are places that do not get cleared to dry pavement, and if you expect to get through, you must be equipped and prepared to drive through on ice. That means chains in most cases, and progress in those conditions is slow. That is somethng to work into your schedule.