I was put on an 8000mg/day(that's not a misprint!) dosage of niacin by the University of San Francisco Medical Center. Niacin helps to increase HDL cholesterol. You have to build to it slowly to be able to take those quantities and have regular liver tests to check for damage. It did raise my HDL but not in sufficient quantity to justify taking that much niacin. I now take slo-niacin 750mg twice per day. I'm not suggesting anyone take anything without consulting their doctor first, I'm just saying that an accidental large dose of niacin will probably do nothing more than give you the biggest flush and itching you've ever had. Water intake helps to flush it thru your system. When you have a coronary bypass at age 26 you become a guinea pig for the doctors...I've tried it ALL!