Lee,
I feel your pain. DW in a memory health issue, like Alzhiemers? likely the read from your post. Others touch upon the financial issues, I surmise you are financially secure and looking to maximize your time with your lady and family with a mobile lifestyle.
Liquidation of assets is complicated, only you can decide the right way, distribute now while you can, or have your personal rep. do it when you pass away
There is no time like today. DW is in a state where she cannot participate, yet you know her wishes. She has certainly worked with you beforehand.
The family home after the loss of a spouse is often a minutae reminder of that lost partner. Is it tempting to go off to a new adventure and leave that home behind?
Yes for the short term, no in the long term. You may need it for your own health issues someday. I prefer a home base when end of life is possible.
Go out , travel, any way you wish. your lady will be with you.