Very nice looking rig, congrats on your purchase. When we looked at our Motorhome with slides that was very important to us as well. For us, the only issue when closed is we can't access a couple drawers in the bedroom and our bedroom wardrobe doors don't open.
We figured it wouldn't be an issue since it was the bedroom. We can still sleep on the bed with the slide in. I've only slept on the bed once with the slide in, but it wasn't a problem. That was at a Flying J for a quick stop over. We've never camped with the slides in.
-Michael