Can tires be off ground on auto leveling system?

I have never seen a leveling system that had lateral support built into it. Leveling systems by name, indicate vertical support not foundational support.

Disclaimer: Just because I have not seen one does not indicate they do not exist.

Your question had to do with a trailer and I have very limited experience in that area but safety first is always best. I would not raise my Motorhome off the ground with the hydraulic jacks.