From Indiana to Virginia, we always took US 35 through Ohio and hooked up with I-64 in West Virginia at Point Pleasant. Ran it through WV. As stated there are some grades to negotiate and I hated the 7% at Sandstone Mountain. So we started to break off onto I-77 at Beckley and take it to I-81. You still have about the same grade, but it is friendlier, with several areas that flatten a bit to cut down your momentum. On 64, it's downhill with a couple 90* curves that I hated. And since I drove it, I made the decisions. To go that way is about 100 miles "out of our way" as my DH would say, but worth it in my view. At that time we had a 41' Phaeton towing a small truck. I do it now in my 25' Coach House not towing and have no anxiety over it.