I would suggest checking that the grounding for the building and the ground/neutral bond are good and solid. Also it would be very wise to check that any other incoming utilities (telephone, cable TV, etc.) have their grounds properly and solidly tied into the electrical ground, as I believe is required by code.
In a house where I used to live that had a hodgepodge of electrical wiring, ranging from old knob-and-tube to quite recent work, I had trouble with surges because the telephone line ground and the electrical system ground were not well connected. Things that connect to both, such as my DSL modem, would give trouble due apparently to differential voltages between the two systems. It was unfortunately not easy to solve the underlying problem as the two utilities entered the house on opposite sides.
480V 400A main would to me imply three-phase 480/277 power, and perhaps an on-premsis transformer to get 120V power (or possibly a separate utility connection). If this is the power supply you have, a surge suppression system would be rather more complex than for a normal house and presumably rather more expensive.