Grumble Snabble Snarf...
These are not precision fuses rated for load. They are Armageddon grade replacements for fusible links, got it?
If the 300-amp fuse blows it's pretty self-explanatory that you have China Syndrome and that isn't subtle.
The smaller rated fuses can be worked around in order to test a circuit. Their actual operating amperage IS NOWHERE NEAR the fail value. Not even close.
Disconnect the smaller fuse circuit.
With a home-made 50-amp breaker, 10 gauge lead wires and crocodile grade jaw clamps, hook this IN SERIES with the breaker circuit you wish to test. Do not try this with a low battery. Nor try with a great load placed upon that circuit.
Testing needs to be done, one additive load at a time. If one particular circuit is on the ra... oops I mean malfunctioning, you'll find it in a hurry.
If the big momma fails you won't need a magnifying glass a Sherlock Holmes hat to find the problem. Connect a 50 watt 12-volt drop cord bulb and standard socket in series with the big breaker and when it goes out or gets really dim you've hit the jackpot.
The in-series 50 watt 12-volt drop light test will also work great for the other fuses too.
Simple CHEAP home-made testing at it's finest.