Can't speak for a Ford, but my Tundra just handled a 4K trip which included Grand Tetons, Yellowstone and Glacier national parks. I was surprised at how well the truck did in the mountains.....but I just let it do the work, so sometimes my speed would drop to around 50. And, I kept my cruisin' speed down to 60-65. Also, I had just installed new tires on trailer and truck. Make sure your tires are good!
Make sure you know how to downshift on the steeper downgrades. Doing so definitely save my brakes. On my old Dodge, I accidently had my brakes smoking by not downshifting....lesson learned.
Just check your tire pressures frequently and monitor all engine fluids. I don't really think you should have a problem.
