I've owned two F450's, a 2010, and the 2016 in my sig. IMHO, they are the closest thing to the perfect TC hauler for me. I can only speak for myself and my needs. With 30 years of TC experience trying many different options and making a few mistakes along the way, I'm very familiar with what works and what doesn't. Both F450's have hauled my 1121 incredibly well, and have only needed upper stableloads to get the overload springs engaged sooner.
I don't tow with the TC ever, and if I did that might sway me toward the cab-chassis models. But I don't need the higher GVWR, lower available trim level, time and expense of adding a bed, etc.
The 2010 was a very comfortable and quiet ride with the TC loaded, the 2016 is even better. They both have a stiffer unloaded ride, but I certainly wouldn't call it horrible. Neither truck was a daily driver for me.
I only know a little about the 2017 F450's, but so far nothing I've read about them has made me regret buying the 2016 model. I know the 2017's have an aluminum body, and the axles are NOT the same as the 2015/2016 models.
I wouldn't hesitate to recommend buying a 2015/2016 F450 for hauling a heavy TC.
:):)