My concern with lower ratios would be the initial pull from a stop when at full loaded weight on a steep grade. Once you get rolling, it is less of a concern. Those guys that have steep driveways or favorite camping spot with some grade are the ones that will suffer at slow speed without the 4.10's.
Although I could have dropped cruising RPM by choosing the 4.10's in my CTD powered 5500, I chose the 4.44's to get me that extra torque multiplication without having to drop into 4wd low range. On the other hand, I did not choose the 4.88's since I do long highway miles that would not be pleasant even at my typical 60-65 mph with that ratio.